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How Nitrogen-Fixing Bacteria Sense Iron

September 17, 2019

In many nitrogen-fixing bacteria, a protein called RirA plays a key role in regulating iron by sensing high levels of the metal and shutting down the production of proteins that bring in more iron. RirA contains a cluster of four iron and four sulfur atoms, which acts as a sensor for iron availability. But until now, exactly how this cluster structure detects iron levels in a cell was unclear, says the University of East Anglia.

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